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KMID : 1188320120060030355
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Gut and Liver
2012 Volume.6 No. 3 p.355 ~ p.361
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Effect of a Diet with Unrestricted Sodium on Ascites in Patients with Hepatic Cirrhosis
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Xi-bing Gu
Xiao-juan Yang
Hong-ying Zhu
Bo-yu Xu
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Abstract
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Background/Aims:There has been debate on whether a sodium-restricted diet (SRD) should be used in cirrhotic patients with ascites in China in recent years. The purpose of this study was to compare the effect of sodium-restricted and unrestricted diets on plasma renin activity (PRA), renal blood flow (RBF) and ascites in patients with liver cirrhosis.
Methods:Two hundred cirrhotic patients with ascites were randomly divided into two groups (98 cases in the sodium-unrestricted diet [SUD] group and 102 cases in the SRD group); 95 patients (96.94%) in the SUD group and 97 patients (95.1%) in the SRD group had post-hepatitis B cirrhosis.
Results:Blood sodium and RBF were higher in SUD group than in SRD group (p<0.001), while PRA were significantly lower in SUD group than the SRD group 10 days after treatment (p<0.001). Renal impairment caused by low blood sodium was higher in SRD group than in SUD group (p<0.01). Ascites disappeared in higher proportion of patients in SUD group than in SRD group (p<0.001).
Conclusions:SUD can increase the level of blood sodium and RBF, and be beneficial to diuresis and ascite reduction and disappearance.
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KEYWORD
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Liver cirrhosis, Ascites, Sodium-unrestricted diet, Albumin, Renal circulation
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